Currently, the main diagnostic methods for NPC include flexible fiberoptic nasopharyngoscopy pathological biopsy, blood EB-DNA testing, computed tomography (CT), magnetic resonance imaging (MRI), emission computed tomography (ECT), and positron emission computed tomography (PET).
Comprehensive analysis of various imaging examinations has great significance for the treatment of patients with NPC. 2, 3 In recent years, imaging has played a key role in the screening, diagnosis, staging, and monitoring of therapeutic interventions for NPC.
It has a high incidence rate in Southeast Asia, Southern China, North Africa, and Alaska. 1 Nasopharyngeal carcinoma (NPC) is a malignant tumor that arises from the epithelium of the nasopharyngeal mucosa and it is common in the head and neck. Cancer is a serious public health concern that has not been well addressed worldwide. Keywords: nasopharyngeal carcinoma, optical imaging, phototherapy, nanoparticleĪlong with the rapid progress of modern society, greater attention and efforts have been dedicated to the health problems of human beings, particularly for cancer. This study is expected to provide a scientific basis for further research and development of NPC diagnosis and treatment. This study aimed to elaborate on the applications of nanoplatform-based optical imaging strategies and treatment modalities, including fluorescence imaging, photoacoustic imaging, Raman spectroscopy imaging, photodynamic therapy, and photothermal therapy. In this review, we aimed to introduce the recent developments in phototheranostics of NPC based on a nanoplatform. Many Chinese and international research teams have applied nano-targeted drugs to optical diagnosis and treatment technology to conduct multimodal imaging and collaborative treatment of NPC, which has become a hot research topic. It has shown great potential in the field of cancer diagnosis and treatment owing to its unique noninvasive advantages.
Phototheranostics in combination with nanoparticles is an integrated strategy for enabling simultaneous diagnosis, real-time monitoring, and administration of precision therapy for nasopharyngeal carcinoma (NPC). *These authors contributed equally to this workĬorrespondence: Jian Zhang Junsheng Liang, Email Ībstract: Nasopharyngeal carcinoma (NPC) is a common malignant tumor of the head and neck with a high incidence rate worldwide, especially in southern China. Yanping Lin, 1, * Ting Qiu, 2, * Yintao Lan, 3, * Zhaoyong Li, 1 Xin Wang, 4 Mengyu Zhou, 3 Qiuyu Li, 1 Yao Li, 1 Junsheng Liang, 1 Jian Zhang 3, 4ġDepartment of Radiology, DongGuan Tungwah Hospital, DongGuan, Guangdong, 523000, People’s Republic of China 2Department of Radiology, Zhuhai People’s Hospital (Zhuhai Hospital Affiliated with Jinan University), Zhuhai, Guangdong, 519000, People’s Republic of China 3Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, Guangdong, 511436, People’s Republic of China 4Department of Oncology, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People’s Hospital, Qingyuan, Guangdong, 511500, People’s Republic of China
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